PaTH began as a partnership of four Mid-Atlantic academic health systems (Penn State Hershey Medical Center, University of Pittsburgh Medical Center, Temple Health System, and Johns Hopkins Health System) that have established governance to operate as an integrated research network. In 2015, the University of Utah and Geisinger Health System also joined PaTH, creating an electronic health record (EHR)-based data infrastructure across three states (Maryland, Pennsylvania, and Utah).